Introduction of new technologies and their applications to neuroblastoma diagnosis, treatment, and therapy assessment are explained. Role of molecular ghenetics in diagnosis and therapy for neuroblastoma patients is detailed. Molecular detection of minimal residual neuroblastoma is described. Magnetic resonance imaging and spectroscopy are detailed for diagnosing this solid, extracranial cancer. Targets for therapeutic intervention in neuroblastoma are identified, including targeting multidrug resistance in this cancer. Ornithine decarboxylase and polyamines are novel targets for therapeutic intervention. The effectiveness of chemotherapy with oral irinotecan and temozolomide is explained. The role of transcription factors (GATA) in neuroblastoma pregression is also included.
Written for a broad audience this book offers a comprehensive account of early warning systems for hydro meteorological disasters such as floods and storms, and for geological disasters such as earthquakes. One major theme is the increasingly important role in early warning systems played by the rapidly evolving fields of space and information technology. The authors, all experts in their respective fields, offer a comprehensive and in-depth insight into the current and future perspectives for early warning systems. The text is aimed at decision-makers in the political arena, scientists, engineers and those responsible for public communication and dissemination of warnings.
The object of this book is to highlight how the nascent field of sustainability science is addressing a key challenges for scientists; that is, understanding the workings of complex systems especially when humans are involved. A consistent thread in the sustainability science movement is the wide acknowledgement that greater degrees of integration across what are now segmented dimensions of extant Science and Technology systems will be a key factor in matching the most appropriate science and technology solutions to specific sustainability problems in specific places.
Covering the basic techniques used in the latest research work, the author consolidates progress made so far, including some very recent and promising results, and conveys the beauty and excitement of work in the field. He gives clear, lucid explanations of key results and ideas, with intuitive proofs, and provides critical examples and numerous illustrations to help elucidate the algorithms. Many of the results presented have been simplified and new insights provided. Of interest to theoretical computer scientists, operations researchers, and discrete mathematicians.
Most of the scientific methods devised for forest planning support timber production ignoring the existence of forest functions other than wood production. Fortunately, the realisation that the forest planning methods available today do not correspond to the needs of today's forestry has activated forest researchers to develop and adopt new methodologies and approaches, which are specifically aimed at multi-objective situations. This book is about the quantitative approach to multi-objective forest planning. The emphasis is on topics that are rather new and not yet systematically applied in forest planning practice. The topics and methodologies discussed in this book include: measurement of preferences, multiple criteria decision analysis, use of GIS to support multi-objective forest management, heuristic optimization, spatial optimisation, and the measurement of non-wood forest outputs. By reading the book, a planning specialist, student or a researcher will get an insight into some of the current developments in forest planning research.
This book springs from a conference held in Stockholm in May June 1988 on Culture, Language and Artificial Intelligence. It assembled more than 300 researchers and practitioners in the fields of technology, philosophy, history of ideas, literature, lin guistics, social science, etc. It was an initiative from the Swedish Center for Working Life, based on the project AI-Based Systems and the Future of Language, Knowledge and Responsibility in Professions within the COST 13 programme of the European Commission. Participants in the conference, or in some cases researchers related to its aims, were chosen to contribute to this book. It was preceded by Knowledge, Skill and Artificial Intelligence ...
This book has passed through a number of editions each involving some modifications while retaining the general character of the first. The most substantial changes occurred in the fifth (1983), but that is now out-of-date. Mycology has not been immune from the rapid evolution of biology in the past decade and the preparation was a long way beyond the capacity of the older writer (C.T.I.). So a younger one (H.J.H.) has collaborated with him. Substantial changes have been made throughout, particularly in relation to taxonomy but in general Chapters 1-7 have undergone relatively little revision. However, this is not true of Chapters 8-12 where the influence of the younger author is paramount. ...