Molecular Biology of RGS Proteins, a volume of Progress in Molecular Biology and Translational Science, will include historical discussion of RGS proteins, the role of RGS proteins in addiction, depression and Parkinson's disease and the biology and functional regulation of RGS9 isoforms. This publication further discusses RGS proteins in cellular signaling, protein control in lymphocyte function, and alternative splicing of RGS transcripts and nuclear RGS proteins, offering the latest in research of RGS proteins.
RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. Brings together information on the current state of the RGS protein field Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery
Hardbound; 8 1/2 x 11 inches; 496 pages; indexed; w/deluxe plastic dust jacket; 85 full-color photos; 354 black & white views; 32 detailed maps; features line drawings of buildings and structures along the RGS by Mike Blazek plus maps and additional structure plans by Jim Key.
The need for greater bandwidth has driven laser manufacturers towards the use of distributed feedback semiconductor (DFB) lasers with a well-defined single mode. These semiconductor diode-based devices are now essential components in a broad range of advanced optical systems. This text covers the materials, operation and design strategies of DFB lasers. It provides detailed accounts of large-signal time-domain numerical modelling techniques, which can be extended to optical systems and components other than DFB lasers. Numerical MATLAB programs are outlined in the text.
Nearly two hundred letters written by the Civil War hero depicted in the film Glory reveal his initial reluctance to accept the command of the North's first black regiment and show how his reluctance soon turned into loyalty and dedication.
Regulator of G protein Signaling (RGS) proteins modulate G protein-mediated signaling by accelerating the GTPase activity of Galpha subunits, thereby shortening the lifetime of active signaling molecules, i.e. Galpha-GTP and free Gbetagamma complexes. Despite extensive studies for a decade, our understanding of the physiological functions of RGS proteins is still in its infancy. The lack of pharmacological inhibitors for RGS proteins and functional redundancy among multiple family members (>30) imposes tremendous challenges for the application of antisense or genetic knockout strategies in assessing the role of RGS proteins in physiological processes. Moreover, another level of complexity li...
On July 18, 1863, the African American soldiers of the Fifty-fourth Massachusetts Infantry led a courageous but ill-fated charge on Fort Wagner, a key bastion guarding Charleston harbor. Confederate defenders killed, wounded, or made prisoners of half the regiment. Only hours later, the body of Colonel Robert Gould Shaw, the regiment's white commander, was thrown into a mass grave with those of twenty of his men. The assault promoted the young colonel to the higher rank of martyr, ranking him alongside the legendary John Brown in the eyes of abolitionists. In this biography of Shaw, Russell Duncan presents a poignant portrait of an average young soldier, just past the cusp of manhood and sti...