This book comprehensively covers the state-of-the-art and cutting-edge technologies in an integrated fashion for applications in ADME studies of small molecular drugs. Each chapter provides descriptions of the technologies, application scope and limitations, optimal conditions for intended results, protocols, case studies, and future developments. By concisely describing these technologies, the book provides a useful tool for drug metabolism scientists and as a reference for scientists in the fields of pharmacology, medicinal chemistry, pharmaceutics, toxicology, bioanalytical science in academia and industry.
The voice that comes through this book is daring rather than desperate, decisive rather than doleful, and fairly composed, given the constraints that govern the lives of the featured poets, as women and as artists.
This book covers recent developments in process systems engineering (PSE) for efficient resource use in biomass conversion systems. It provides an overview of process development in biomass conversion systems with focus on biorefineries involving the production and coproduction of fuels, heating, cooling, and chemicals. The scope includes grassroots and retrofitting applications. In order to reach high levels of processing efficiency, it also covers techniques and applications of natural-resource (mass and energy) conservation. Technical, economic, environmental, and social aspects of biorefineries are discussed and reconciled. The assessment scales vary from unit- to process- and life-cycle or supply chain levels. The chapters are written by leading experts from around the world, and present an integrated set of contributions. Providing a comprehensive, multi-dimensional analysis of various aspects of bioenergy systems, the book is suitable for both academic researchers and energy professionals in industry.
"Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. the Ebook series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery. the Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.
Activity theory holds that the human mind is the product of our interaction with people and artifacts in the context of everyday activity. Acting with Technology makes the case for activity theory as a basis for understanding our relationship with technology. Victor Kaptelinin and Bonnie Nardi describe activity theory's principles, history, relationship to other theoretical approaches, and application to the analysis and design of technologies. The book provides the first systematic entry-level introduction to the major principles of activity theory. It describes the accumulating body of work in interaction design informed by activity theory, drawing on work from an international community of scholars and designers. Kaptelinin and Nardi examine the notion of the object of activity, describe its use in an empirical study, and discuss key debates in the development of activity theory. Finally, they outline current and future issues in activity theory, providing a comparative analysis of the theory and its leading theoretical competitors within interaction design: distributed cognition, actor-network theory, and phenomenologically inspired approaches.